Platelet-Rich Fibrin (PRF)

Your body's own healing intelligence — concentrated.

PRF (Platelet-Rich Fibrin) is the most advanced form of regenerative blood-derived therapy available in aesthetic medicine. Unlike PRP, which uses a liquid plasma concentrate, PRF produces a fibrin matrix — a slow-release scaffold that delivers growth factors to the tissue over days and weeks rather than hours. The result is a more sustained, natural regenerative response.

The process begins with a small blood draw. Your blood is centrifuged at a lower speed than traditional PRP, preserving more platelets, white blood cells, and stem cells within a fibrin network. This concentrated matrix is then injected or applied topically to stimulate collagen production, improve skin quality, and restore volume.

PRF contains no additives, anticoagulants, or synthetic substances — it is entirely your own biology. This makes it one of the safest and most biocompatible treatments in regenerative aesthetics, with virtually no risk of allergic reaction or rejection.

A slow-release scaffold for lasting regeneration

Fibrin Matrix Scaffold

Unlike liquid PRP, PRF forms a three-dimensional fibrin scaffold at the injection site. This matrix acts as a slow-release reservoir for growth factors — delivering regenerative signals to the surrounding tissue over 7–14 days rather than dissipating within hours.

Growth Factor Release

PRF is rich in PDGF, TGF-β, VEGF, EGF, and IGF — growth factors that signal fibroblasts to produce new collagen and elastin, stimulate angiogenesis (new blood vessel formation), and accelerate tissue repair and regeneration.

Stem Cell Preservation

The lower centrifuge speed used to prepare PRF preserves mesenchymal stem cells that are lost in traditional PRP processing. These stem cells contribute to tissue regeneration and long-term skin quality improvement.

Bio Filler Application

When processed into a gel (PRF gel or "bio filler"), the fibrin matrix can be injected as a natural volumizer — restoring lost volume under the eyes, in the cheeks, and along the jawline using only your own biology.

What patients report

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Natural volume restoration without synthetic filler

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Stimulated collagen and elastin production

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Improved skin texture, tone, and radiance

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Reduced under-eye hollowing and shadowing

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Softened fine lines and surface wrinkles

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Enhanced skin hydration and barrier quality

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Gradual, natural-looking results that build over weeks

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Virtually zero risk of allergic reaction — entirely your own biology

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Complementary to microneedling, PRP, and other regenerative protocols

Who is a good candidate for PRF?

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Adults seeking natural volume restoration without synthetic fillers

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Those with under-eye hollowing, tear trough shadowing, or midface volume loss

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Individuals wanting to improve overall skin quality and radiance

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Patients who prefer a fully biological, additive-free treatment

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Those with fine lines, dull skin, or early signs of aging

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Anyone seeking a regenerative complement to existing aesthetic treatments

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Patients with a history of filler reactions or sensitivity to synthetic substances

Common questions

What is the difference between PRF and PRP?

PRP (Platelet-Rich Plasma) is a liquid concentrate of platelets in plasma, prepared at higher centrifuge speeds. PRF (Platelet-Rich Fibrin) is prepared at lower speeds, producing a fibrin matrix that retains more platelets, white blood cells, and stem cells. The fibrin scaffold releases growth factors slowly over 7–14 days, producing a more sustained regenerative response than PRP's faster but shorter release.

How many PRF sessions will I need?

Most patients see meaningful improvement after 2–3 sessions spaced 4–6 weeks apart. For volume restoration (bio filler), 1–2 sessions may be sufficient. For skin quality improvement, a series of 3 sessions is typically recommended, followed by maintenance every 6–12 months.

When will I see results?

Because PRF works through gradual collagen stimulation, results develop over 4–8 weeks after each session. You may notice improved skin quality and subtle volume changes within 2–4 weeks, with full results visible at 6–8 weeks. Results continue to improve with each subsequent session.

Is PRF painful?

A topical numbing cream is applied before treatment. The blood draw is a standard venipuncture — brief and well-tolerated. Injections are performed with fine needles or cannulas and are generally well-tolerated with numbing. Mild swelling and bruising at injection sites is common for 2–5 days.

Can PRF be combined with other treatments?

Yes — PRF is highly complementary to microneedling (applied topically during the procedure), dermal filler (used alongside HA filler for a combined approach), and other regenerative protocols. Your clinician will design a sequenced treatment plan based on your goals.

How long do PRF results last?

Results from PRF bio filler typically last 9–12 months, as the fibrin matrix is gradually metabolized and replaced by your own collagen. Skin quality improvements from PRF injections can last 12–18 months with a proper maintenance protocol.

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